皮脂腺(sebaceous glands)的基本生理功能是产生皮脂以滋润皮肤和毛发,加强皮肤的屏障功能,控制皮肤表面微生物的生长,并参与调节皮肤炎症和免疫应答。皮脂腺的功能失调在痤疮、脂溢性皮炎、特应性皮炎等常见皮肤病的发病机制中起着重要作用。内源性大麻素系统(endocannabinoid system)是一种复杂的稳态调控信号网络,由内源性大麻素、大麻素受体、以及参与内源性大麻素转运、合成和降解的酶组成。近年的研究发现内源性大麻素系统的各组分在皮脂腺中都有表达,并且参与皮脂腺功能的调控,表明其在皮脂腺功能障碍相关皮肤病防治中具有潜在应用前景。本文就内源性大麻素系统对皮脂腺功能的调控作用研究进展进行综述。

The main function of sebaceous glands (SG) is producing sebum, which is an integral component of the skin barrier, regulates the growth of cutaneous microbiota via its acid and antimicrobial lipid content, and modulates skin inflammation and immunity. Dysfunctions of SG play critical roles in the pathogenesis of common dermatoses such as acne, seborrhea, and atopic dermatitis. The endocannabinoid system (ECS) is a complex homeostatic signaling network that comprises endocannabinoids, cannabinoid receptors, and enzymes responsible for endocannabinoid transport, synthesis, and degradation. Recent evidence has indicated the expression and functional involvement of ECS components in human SGs, suggesting the therapeutic potential of ECS modulation in the management of SG-associated diseases. This review provides an overview of research progress on the regulatory effects of ECS on SG functions.