缺氧性细胞损伤(hypoxic cell damage)参与多种疾病的发生,严重危害人类的健康,因而对缺氧性细胞损伤机制的深入探索具有重要意义。目前的研究表明缺氧性细胞损伤的发生机制主要与细胞凋亡、自噬、焦亡、铁死亡、铜死亡及parthanatos密切相关。本文主要总结缺氧性细胞损伤的发生机制,阐明其关键因子及其调控机制,以期为涉及缺氧性细胞损伤的相关疾病的防治提供新思路。

Hypoxic cell damage is implicated in the etiology of various diseases, posing a significant threat to human health. Therefore, a comprehensive exploration of the underlying mechanisms of hypoxic cell damage is of crucial importance. Recent research has elucidated a compelling correlation between hypoxic cell damage and key cellular processes, including apoptosis, autophagy, pyroptosis, ferroptosis, cuproptosis, and parthanatos. The aim of this article is to integrate current knowledge on the mechanisms underlying hypoxic cell injury. It seeks to clarify the critical determinants and regulatory pathways involved in these processes, and to offer innovative perspectives on preventive and therapeutic approaches for hypoxia-induced diseases.