随着肿瘤化学治疗的快速发展,肿瘤患者总体生存率得以不断延长。然而,化疗产生的心血管毒副作用严重制约肿瘤治疗效果,已成为影响患者生存质量和生存率的高危风险因素。其中,化疗相关血管内皮损伤(vascular endothelial injury)可破坏血管稳态,是急性血管事件(血管痉挛、急性心肌梗死、脑卒中等)、动脉粥样硬化、高血压以及动脉瘤等心血管毒副反应的病理基础。探讨化疗相关血管内皮损伤的机制及保护策略具有重要临床意义。本文拟对化疗血管内皮损伤机制和相关保护策略的最新进展进行综述。

With the rapid development of tumor chemotherapy, the overall survival of tumor patients has been continuously prolonged. However, the cardiovascular toxic side effects caused by chemotherapy seriously limit the effectiveness of tumor treatment, and have become a high-risk factor affecting the quality of life and survival rate of patients. Among them, chemotherapy-related vascular endothelial injury can disrupt vascular homeostasis, which serves as the pathological basis of cardiovascular toxic side effects such as acute vascular events (vasospasm, acute myocardial infarction, stroke, etc.), atherosclerosis, hypertension, and aneurysms. Exploring the mechanisms and protective strategies of chemotherapy-related vascular endothelial injury is of great clinical significance. This review aims to summarize the latest progress in the mechanisms of chemotherapy-associated vascular endothelial injury and related protective strategies.