阿尔茨海默病(Alzheimer's disease,AD)是一种渐进性神经退行性病变,目前其发病机制尚未明晰。新近研究发现,肠道菌群可通过影响中枢神经系统功能而影响宿主的认知与行为,可能是治疗神经退行性疾病的重要靶标。肠道菌群稳态失调与肠壁生理屏障破坏可诱发外周系统炎症反应,通过介导神经递质及菌群分泌物等生理活性物质的释放而影响神经发生、神经元间的信号通讯,导致中枢神经发生炎症反应,协同作用加剧神经损伤进程,推动AD病理发展。因此,深入探究肠道菌群稳态失调影响AD发生发展的可能机制可为防治和缓解AD 提供新的视角,为促进健康老龄化提供新策略。

Alzheimer's disease (AD) is a progressive neurodegenerative disease, the pathogenesis of which remains unclear. Recent studies have shown that the gut microbiota can affect the host’ s cognition and behavior by affecting central nervous system function, making it a potential therapeutic target for neurodegenerative diseases. Dysbiosis of the gut microbiota and disruption of the intestinal physiological barrier can induce peripheral inflammatory responses, which, through mediating the release of physiologically active substances such as neurotransmitters and microbiota secretions, can affect neurogenesis and neuronal signaling, resulting in inflammatory reactions in the central nervous system, synergistically promoting the neurodegenerative progression of AD pathology. Therefore, investigations into the possible mechanisms by which dysbiosis of the gut microbiota affects the pathology of AD may provide new perspectives for the prevention and alleviation of AD, offering new strategies for promoting healthy aging.