骨重塑是维持骨稳态(bone homeostasis)的重要过程,人们通常认为骨重塑主要接受内分泌激素调节。近年来,越来越多的证据表明,中枢神经系统通过传出神经直接参与骨稳态调节。虽然,大脑和骨骼组织之间已被证实存在明确的神经连接,但这些神经联系在大脑调节骨稳态中的作用还不十分清楚。本文将关注骨与脑之间的神经联系,分别从中枢神经系统和神经环路(neural circuit)、自主神经系统以及感觉神经系统对骨稳态的调控等方面介绍大脑调控骨代谢(bone metabolism)领域的最新进展。

Bone remodeling is an important process for maintaining bone homeostasis, and it is commonly believed that bone remodeling is mainly regulated by endocrine hormones. In recent years, there has been increasing evidence suggesting that the central nervous system is directly involved in regulating bone homeostasis through efferent nerves. Although it has been demonstrated that there are clear neural connections between the brain and skeletal tissues, the role of these neural connections in the brain's regulation of bone homeostasis is not well understood. In this paper, we will present recent advances in the field of brain regulation of bone metabolism, focusing on the neural connections between bone and brain, the regulation of bone homeostasis by the central nervous system and neural circuit, the regulation of bone homeostasis by the autonomic nervous system and sensory nervous system, respectively.