Claudin-10是紧密连接跨膜蛋白claudin家族的一员,在多个器官和组织的上皮细胞中表达,存在claudin-10a与10b两种同工型。Claudin-10具有维持细胞膜选择透过性和调节离子经旁细胞途径转运的作用。近年来,claudin-10已被报道与多种疾病的发生发展过程相关。Claudin-10基因突变导致的多种器官功能受损的疾病被命名为HELIX综合征,患者具有无汗症、肾病、低钾血症、口干症及严重的牙釉质磨损等临床表现。本文将对claudin-10的分子结构、表达与分布、功 能与疾病关系等方面的研究进展进行综述。

Claudin-10, a member of the claudin family of tight junction transmembrane proteins, is expressed in epithelial cells of multiple organs and tissues, with two isoforms, claudin-10a and claudin-10b. It plays a critical role in maintaining the selective permeability of cell membrane and regulating ion transport through the paracellular pathway. In recent years, claudin-10 has been reported to be associated with the development and progression of a variety of diseases. Diseases characterized by impaired function of multiple organs due to mutations in the claudin-10 gene are collectively referred to as HELIX syndrome, which generally results in clinical manifestations such as anhidrosis, renal disease, hypokalemia, xerostomia, and severe enamel wear. In this review, the research progress on claudin-10 will be presented, including its molecular structure, expression and distribution, as well as the relationship between claudin-10 function and diseases.