骨骼对于支持肌肉和保护重要器官至关重要,也是钙和磷的储存池。骨骼是人体代谢最活跃的组织之一,其不断更新以适应健康所需。为了维持正常的骨骼相关细胞的生理功能,需要足够的氧气,因为有证据表明缺氧可能影响骨骼健康。低氧与骨质疏松形成之间的关系一直是近年热点研究话题。低氧在骨组织各细胞增殖、分化、凋亡及保持稳定等多方面扮演重要角色,深度参与骨重塑过程。本文在现有的相关文献报告基础上,对低氧与骨稳态、骨质疏松症的关系进行综述,以期对骨质疏松的防治提供参考。

Bone is essential for supporting muscles and protecting vital organs, as well as serving as a reservoir for calcium and phosphorus. As one of the most metabolically active tissues in the body, bone undergoes constant remodeling to meet the demands of health. Adequate oxygen is required to maintain the physiological functions of bone cells, as evidence suggests that hypoxia may affect bone health. The relationship between hypoxia and osteoporosis has become a recent hot topic in research. Hypoxia plays a critical role in various aspects of bone tissue, including cell proliferation, differentiation, apoptosis, and maintenance of stability, and is deeply involved in bone remodeling. This article reviews the existing reports on the relationship between hypoxia and bone homeostasis, as well as osteoporosis, with the aim of providing a reference for future prevention and treatment of osteoporosis.