程序性细胞死亡在维持机体生长发育、内环境稳态及组织器官正常生理功能中具有举足轻重的作用。铁死亡抑制蛋白1(ferroptosis suppressor protein 1, FSP1)不仅能诱导细胞发生凋亡,还参与抗细胞铁死亡,此截然相反的调节作用取决于其细胞定位,但具体调控机制仍不明确。本文就FSP1在两种程序性细胞死亡中的作用及调控机制作一综述,以期在程序性细胞死亡相关疾病中精确调控FSP1的表达及其分布,为肿瘤、神经退行性病变等相关疾病诊治提供新的策略。

Programmed cell death plays a critical role in maintaining organism growth and development, homeostasis and physiological functions of organs. Ferroptosis suppressor protein 1 (FSP1) is capable of regulating not only apoptosis but also ferroptosis, mainly dependent on its intracellular distribution, yet associated mechanisms still unclear. This review summarizes the role and regulatory mechanism of FSP1 in two types of programmed cell death, by which new strategies can be provided for the diagnosis and treatment of tumors, neurodegenerative diseases and other diseases related to programmed cell death via precisely regulating the expression and distribution of FSP1 in cells.