IL-17是一种重要的促炎细胞因子,在炎症性疾病和自身免疫性疾病中发挥重要作用。研究发现,除Th17细胞外,γδT17细胞也是IL-17的重要来源。γδT17细胞参与多种免疫应答过程, 与感染性疾病、自身免疫性疾病和肿瘤等疾病的发生发展密切相关,本文综述γδT17细胞活化机制的研究进展,探明γδT17细胞的分化和活化机制将为上述疾病的治疗提供新思路。

IL-17 is an important pro-inflammatory cytokine, which has attracted widespread attention due to its crucial roles in inflammatory and autoimmune diseases. Studies have shown that in addition to Th17 cells, γδT17 cells are also vital sources of IL-17. γδT17 cells are intimately involved in multiple immune responses and closely associated with the occurrence and development of diverse diseases, such as infectious diseases, autoimmune diseases and tumors. This article summarizes the research advances in the mechanism of activation of γδT17 cells and elucidates the mechanism of the differentiation and activation of γδT17 cells, which is expected to provide new ideas for the treatment of the associated diseases.