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New Method and Technology

The Construction and Research Progress of Vascularized Organoids

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  • (Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China)

Online published: 2019-01-01

Abstract

Organoids with structural and functional similarity to their real counterparts have become a widely used supplementary model. However, due to the insufficient blood perfusion, the existing organoids still have problems such as limited growth and development, serious internal necrosis, and incomplete structure and function. As an important component of many organs, blood vessels can not only solve the problem of material transport, but also provide the mechanical forces of blood perfusion. In addition, vascular endothelium can secrete various factors to regulate the development and maturation of organoids. Therefore, vascularized organoids possess broader development and application prospects.This article reviews the cell sources for constructing vascularized organoids and introduces existing methods by which vascularized organoids might be obtained,such as the co-differentiation of stem cells,co-culture and self-assembly of multiple cells, the direct use of microvascular fragments, in vivo revascularization after transplantation and tissue engineering techniques.

Cite this article

MA Xiao-Jing,HONG Zi-Xuan,ZHU Shun-Tian,WU Run-Long,YUAN Qi-Hang,WANG Kai△ . The Construction and Research Progress of Vascularized Organoids[J]. Progress in Physiological Sciences, 0 : 104 -109 . DOI: 10.20059/j.cnki.pps.2023.02.1107

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