Ischemic stroke is a cerebrovascular disease caused by a regional disruption of cerebral blood flow to the brain. Although rapid and effective regeneration of the ischemic brain tissue is crucial to the treatment of ischemic stroke, there exists a risk of reperfusion injury during regeneration. The underlying mechanism of cerebral ischemia-reperfusion injury (CIRI) is complex, involving multiple pathological processes and signaling pathways. Ferroptosis is a new form of non-apoptotic cell death that has aroused extensive concern in recent years, during which process lipid peroxidation and iron overload play crucial roles while mitochondrial ferritin may be protective. Multi-target and multi-pathway as the advantages, traditional Chinese medicine (TCM) may be a new direction targeted at ferroptosis for future treatment of CIRI. This article reviews the characteristics and pathogenesis of ferroptosis and investigates the current status of TCM interventions in ferroptosis, providing a reference for further enhancing the efficacy of TCM in the treatment of ischemic stroke.