癫痫(epilepsy)是儿童常见的慢性脑疾病,反复的癫痫发作可引起不可逆的脑损伤,给患儿及其家庭带来沉重的负担。临床实践中约有三分之一病例为药物难治性癫痫患者,饱受反复惊厥发作的痛苦,亟需寻找新的治疗干预措施。研究发现,作为自噬关键分子的Sequestosome 1/p62可能通过其多功能结构域参与调节多种信号通路,包括哺乳动物雷帕霉素靶蛋白复合物1 (mTORC1)信号通路及炎症信号通路。进一步探索p62蛋白在癫痫中的作用及潜在机制具有重要意义。本文就p62蛋白结构及功能进行探讨,并对其在癫痫中的可能作用、相关机制及潜在治疗意义进行综述。

Epilepsy is a common chronic neurological disease in children, whose recurrent seizures tend to cause irreversible brain damage and bring heavy burdens to their families. Currently, approximately one-third of patients with epilepsy are refractory to medical treatment and constantly suffer from recurrent seizures. Therefore, new therapeutic strategies are in urgent need. Recent studies have found that sequestosome 1/p62, a key molecule of autophagy, may be involved in regulating multiple signaling pathways through its multifunctional domains, including mammalian target of rapamycin complex 1 (mTORC1) signaling and inflammatory signaling pathways. Therefore, it is of great significance to explore the role of p62 protein in epilepsy and the underlying mechanisms. This article discusses the structure and function of p62 protein and reviews the associated mechanisms and potential therapeutical effects of p62 protein in epilepsy.